Demarcation Laser Photocoagulation Extinguished PET/CT Avidity for Choroidal Melanoma
March 30, 2023: In research supported by The Eye Cancer Foundation, a new article published in the Canadian Journal of Ophthalmology reveals a case where PET/CT was used to evaluate the metabolic activity of a choroidal melanoma after radiation therapy. In this case, the PET/CT found persistent metabolic activity in a choroidal melanoma that enlarged after ophthalmic plaque therapy.
But then, after secondary treatment with transpupillary thermotherapy (TTT) the metabolic activity lights went out! Fifteen years later, the patient is alive, well, and has 20/20 vision.
In treatment of choroidal melanoma, failure of local control has been found to be associated with a hazard ratio that is 6.3 times greater for the development of metastatic disease. While ophthalmoscopy, photography, optical coherence tomography, angiography, ultrasonography, and radiologic imaging have been used to detect or assess failure of uveal melanoma treatment, PET SUVs have emerged as a way to quantify uveal melanoma metabolic activity.
Herein we present a case in which PET/CT was used evaluate the metabolic activity of a choroidal melanoma found to enlarge after ophthalmic plaque radiation therapy. This resulted in the use of a transpupillary thermotherapy (TTT) laser for eye salvage.
But then, after secondary treatment with transpupillary thermotherapy (TTT) the metabolic activity lights went out! Fifteen years later, the patient is alive, well, and has 20/20 vision.
In treatment of choroidal melanoma, failure of local control has been found to be associated with a hazard ratio that is 6.3 times greater for the development of metastatic disease. While ophthalmoscopy, photography, optical coherence tomography, angiography, ultrasonography, and radiologic imaging have been used to detect or assess failure of uveal melanoma treatment, PET SUVs have emerged as a way to quantify uveal melanoma metabolic activity.
Herein we present a case in which PET/CT was used evaluate the metabolic activity of a choroidal melanoma found to enlarge after ophthalmic plaque radiation therapy. This resulted in the use of a transpupillary thermotherapy (TTT) laser for eye salvage.
Read the full article here: https://www.canadianjournalofophthalmology.ca/article/S0008-4182(23)00045-5/fulltext
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