AJCC 8th edition TNMH Retinoblastoma Staging: The One Multi-Purpose Staging System
August 3, 2021: Funded by The Myrna and John Daniels Family, The Paul Finger Fund and The Eye Cancer Foundation, an internet-based data-research repository was created to evaluate the American Joint Committee on Cancer (AJCC) staging system for retinoblastoma (RB) and answer important clinical questions that have confounded specialists around the world. That is why 18 RB specialist centers from 13 countries on 6 continents worked together to contribute and analyze data from a combined 2190 retinoblastoma patients.
This AJCC Ophthalmic Oncology Task Force found that the AJCC-RB classification worked better than the currently used classifications which focused on ocular survival. In contrast, the task force showed that the new AJCC RB classification could be used to predict patient survival, ocular survival and included both extraocular tumor extension and the heritable form.
Note that the 8th edition AJCC RB Staging System:
1. Is comprehensive predicting both risk of metastasis and eye-globe salvage.
2. Stages both intraocular and extraocular RB extension.
3. Is dynamic, ever evolving as it is updated based on current medical evidence.
4. Utilizes TNMH staging, as has been commonly used by pediatric, medical and radiation oncologists for all other cancers around the world.
The Eye Cancer Foundation sponsored fellow, Ankit Tomar, MD, led this effort and then showed that this same registry information could be used to investigate the impact of intraocular retinoblastoma seeding on AJCC RB Staging.
Retinoblastoma (RB) is often non-cohesive, resulting in intraocular dissemination of tumor seeds in the subretinal or vitreous space on tumor growth. Seeds are typically looks like dust, sphere or clouds. Presence of retinoblastoma seeds is thought to worsen local tumor control. As published in the British Journal of Ophthalmology, Tomar and the AJCC Ophthalmic Oncology Task Force registry found that….. 2-3 point summary.
Click here to read the articles regarding the study.
Read more about the results here!
https://bjo.bmj.com/content/early/2021/08/01/bjophthalmol-2021-318892
This AJCC Ophthalmic Oncology Task Force found that the AJCC-RB classification worked better than the currently used classifications which focused on ocular survival. In contrast, the task force showed that the new AJCC RB classification could be used to predict patient survival, ocular survival and included both extraocular tumor extension and the heritable form.
Note that the 8th edition AJCC RB Staging System:
1. Is comprehensive predicting both risk of metastasis and eye-globe salvage.
2. Stages both intraocular and extraocular RB extension.
3. Is dynamic, ever evolving as it is updated based on current medical evidence.
4. Utilizes TNMH staging, as has been commonly used by pediatric, medical and radiation oncologists for all other cancers around the world.
The Eye Cancer Foundation sponsored fellow, Ankit Tomar, MD, led this effort and then showed that this same registry information could be used to investigate the impact of intraocular retinoblastoma seeding on AJCC RB Staging.
Retinoblastoma (RB) is often non-cohesive, resulting in intraocular dissemination of tumor seeds in the subretinal or vitreous space on tumor growth. Seeds are typically looks like dust, sphere or clouds. Presence of retinoblastoma seeds is thought to worsen local tumor control. As published in the British Journal of Ophthalmology, Tomar and the AJCC Ophthalmic Oncology Task Force registry found that….. 2-3 point summary.
Click here to read the articles regarding the study.
Read more about the results here!
https://bjo.bmj.com/content/early/2021/08/01/bjophthalmol-2021-318892
