Murat TUNC, Prof. MD
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- Ophthalmic Oncologist
Education and Fellowships
- Ocular Oncology, University of California San Francisco
- Doheny Eye Institute
- Wilmer Eye Hospital, Johns Hopkins University
- Board certifications
- ECFMG Certified
- Department of Ophthalmology, Dokuz Eylul University, Izmir, Turkey Meical School
- Medical school
- Ankara University Medical School
Professor in Ocular Oncology and Orbit
Tunc Eye Clinic
Murat TUNC, MD, Ophtalmology
Professor in Ophthalmology, Ocular Oncology, Orbit and Oculoplastic Surgery
Tunc Eye Clinic
Fields of Expertise: Ocular Oncology, Uveal Melanoma, Retinoblastoma, Orbit, Neuro-Ophthalmology, Medical Retina, Orbital Surgery, Oculoplastic Surgery, Strabusmus, Glaucoma, Phaco surgery, Ocular Surface Reconstruction, Stem Cell Therapy.
Professor in Ophthalmology: 2006-Continues
Fulbright International Fellow in Retina: 2004 (Doheny Eye Institute, University of Southern California; Mentor: Prof. Mark Humayun).
Ocular Oncology and Orbit Fellowship: 1996-1997 (UCSF, University of California, San Francisco; Mentor: Prof. Devron Char).
Neuro-ophthalmology Fellowship: 1994 (Wilmer Eye Institute, Johns Hopkins University; Mentor: Prof. Neil Miller).
Eye MD: 1992-1996 (Department of Ophthalmology, Dokuz Eylul University, Izmir, Turkey).
MD: 1986-1992 (Ankara University Medical School, Ankara, Turkey.
ECFMG Certificate: (Valid Indefinetely)
Ophthalmic Oncology Group (OOG) Membership
American Academy of Ophthalmology Membership
TOEFL (Proficiency in English)
Intraepithelial and invasive squamous cell carcinoma of the conjunctiva: analysis of 60 cases.
clinical features, treatment results, and recurrence rates in patients with either intraepithelial or invasive squamous cell carcinoma of the conjunctiva.
Laboratory evaluation of hypercoagulable states in patients with central retinal vein occlusion who are less than 56 years of age
To investigate whether hypercoagulability plays a role in thrombus formation in patients with central retinal vein occlusion (CRVO) who are less than 56 years of age. RESULTS: Hyperhomocysteinemia and circulating antiphospholipid antibodies were significantly more common in CRVO patients (P < 0.05) compared with age-matched controls. CONCLUSIONS:Hypercoagulability may play a role in the pathogenesis of CRVO in patients less than 56 years old.
Ocular findings in 55 patients with Down's syndrome
29 (52.7%) hypermetropes, 7 (12.7%) emmetropes, and 7 (12.7%) myopes; astigmatism of more than 3.00 diopters was present in 7 (12.7%) patients. Strabismus was observed in 12 patients. Congenital nasolacrimal duct obstruction was present in 12 subjects (21.8%). Blepharitis was found in 19 (34.5%) cases. Nystagmus occurred in 7(12.7%) patients. Brushfield spots were in only 20(36.3%) of the patients and were more common in light-colored irides. Lens opacities were diagnosed in 11 (20%) patients
A new mutation of the fukutin gene in a non-Japanese patient
Fukuyama-type congenital muscular dystrophy (FCMD), Walker–Warburg syndrome, and muscle-eye-brain disease are clinically similar autosomal recessive disorders characterized by congenital muscular dystrophy, cobblestone lissencephaly, and eye anomalies. FCMD is frequent in Japan, but no FCMD patient with confirmed fukutin gene mutations has been identified in a non-Japanese population. Here, we describe a Turkish CMD patient with severe brain and eye anomalies.
Orbital lymphangioma: an analysis of 26 patients
To evaluate retrospective data on the clinical findings, histological features, radiological diagnosis, and management outcomes in orbital lymphangioma. METHODS Data on 26 orbital lymphangioma patients managed over 16 years were re-evaluated. The computed tomograph and magnetic resonance scans and histological slides were reviewed. Parametric techniques were used to assess correlations among clinical, radiological, and histopathological factors.
Posterior sub–Tenon’s capsule triamcinolone injection combined with focal laser photocoagulation for diabetic macular edema
To investigate the efficacy of posterior sub-Tenon’s capsule triamcinolone injection (PSTI) combined with focal laser (FL) photocoagulation in treatment of diffuse clinically significant diabetic macular edema (CSME). Design Prospective randomized clinical study.
Hypercoagulable states and central retinal vein occlusion
Central retinal vein occlusion is a common cause of permanent visual loss. Work up and laboratory evaluation of patients requires the clinician to rule out hypertension, diabetes, hyperlipidemia, and glaucoma. Patients without an identifiable risk factor are often subject to extensive testing for primary and secondary thrombophilias.
Reversible thermoresponsive adhesives for implants
The present invention relates to thermoresponsive adhesives. The invention further relates to methods for the reversible attachment of retinal implants, other implants, and drug delivery devices.
Cystoid macular oedema following pneumatic retinopexy vs scleral buckling
To determine the incidence of angiographic cystoid macular oedema (CMO) following pneumatic retinopexy (PR) and scleral buckling (SB) in consecutive case series. Methods Patients who had successful anatomical attachment following PR and SB were included in our study; 132 patients had PR and 121 patients had SB.
Relation between platelet indices and branch retinal vein occlusion in hypertensive patients
MPV values were significantly higher in BRVO patients compared with the control subjects (8.01±0.79 vs 7.52±0.32 fL, respectively; P< 0.001). Conclusion: MPV is significantly higher in patients hypertensive BRVO patients and further investigations regarding its potentially use as a prognostic biomarker in patients with BRVO are needed.
A reversible thermosensitive adhesive for retinal implants: in vivo experience with plasma-deposited poly (N-isopropyl acrylamide)
Intraoperative retinal adhesion occurred in all eyes with ppNIPAM coated parylene and PDMS implants. Two eyes developed retinal tears during the implantation procedure and the ppNIPAM coated implants
Topical cyclosporine-A combined with mitomycin C for conjunctival and corneal squamous cell carcinoma
To determine the efficiency of topical cyclosporine-A (CSA) combined with mitomycin C (MMC) as an adjunctive treatment in diffuse conjunctival and corneal squamous cell carcinoma (CCSC).
Non-Hodgkin lymphoma and Kaposi sarcoma in an eyelid of a patient with acquired immunodeficiency syndrome: Multiple viruses in pathogenesis
This collision tumor is an unusual presentation of 2 malignant neoplasms in a patient with acquired immunodeficiency syndrome, with in situ hybridization evidence of Epstein-Barr virus and Kaposi sarcoma-associated herpesvirus in the lesion.
Calcium antagonists in N-methyl d-aspartate-induced retinal injury
Our results indicate that ganglion cells of the retina were preserved mostly by nimodipine, followed by combined nimodipine–dantrolene, and dantrolene respectively.
Vertical conjunctival bridge flaps in pterygium surgery
To evaluate the recurrence rates and clinical outcome following pterygium surgery using a vertical conjunctival bridge flap technique.
Obstructive sleep apnoea syndrome in patients with primary open-angle glaucoma
he intra-ocular pressure of patients with primary open-angle glaucoma with obstructive sleep apnoea syndrome was significantly lower than those without obstructive sleep apnoea syndrome (P= 0.006 and P= 0.035 for the right and left eyes, respectively).
Branch retinal vein occlusion associated with tamoxifen use
amoxifen is a selective estrogen receptor modulator widely used in the treatment of hormone-responsive breast cancer. Although branch retinal vein occlusion is rare, careful evaluation of patients on tamoxifen therapy with visual symptoms is required.
Bilateral severe visual loss in brucellosis
Bilateral loss of vision developed within two weeks in a young adult with positive Brucella antibodies. There was optic disc swelling with optic neuropathy and serous retinal detachment in both eyes. The patient had chronic active brucellosis confirmed by serum antibody titers (1/640).
Serous retinal detachment and cystoid macular edema in a patient with Wyburn-Mason syndrome
Wyburn-Mason syndrome is a rare phacomatosis characterized by unilateral arteriovenous malformations (AVMs) involving the brain, retina, and (rarely) the skin. The diagnosis is concluded with dilated fundus examination and markedly dilated tortuous vascular loops with arteriovenous communications on fluorescent angiography.
Premacular hemorrhage due to isotretinoin use
Here, we present a 19-year-old female patient who developed premacular hemorrhage and consequent loss of vision in the left eye after oral use of isotretinoin. To the best of our knowledge, this is the first report of the development of premacular hemorrhage as a result of isotretinoin use.
Bilateral multifocal choroidal carcinoid: long-term follow-up without treatment
Carcinoid tumors metastatic to the choroid may remain stationary for an extended period. Treatment may be deferred until tumor growth, exudative retinal detachment, or substantial impairment of vision develops.
Susac's syndrome: a case of simultaneous development of all three components of the triad
Susac's syndrome is characterized by the clinical triad of encephalopathy, branch retinal artery occlusions and sensorineural hearing loss. We here report a case of 46 year old woman with a sudden diminution in visual acuity at the left eye, headache and decreased hearing at the right ear with mild confusion considered as Susac's syndrome with complete triad.
Ossifying fibroma of the lateral orbital wall in an adult
Orbital ossifying fibroma is an extremely rare condition, especially in adults. This rare tumor mostly develops at the medial wall of the orbit. We report a histopathologically confirmed ossifying fibroma involving the lateral orbital wall in an adult. This case suggests that orbital ossifying fibroma should be considered in the differential diagnosis of orbital bony lesions in adults
Calcification at the posterior pole in scleritis
e believe that subtle posterior scleral inflammation might lead to sclerochoroidal calcification which might be dystrophic in nature.
Maculopathy following extended usage of Clomiphene citrate
Several dose-related ocular side effects have been defined, such as blurred vision, scotomata, diplopia, photophobia, temporary visual impairment, and retinal vein occlusion. 2, 3 Although these adverse ocular effects generally disappear within a few days to weeks following discontinuance of therapy, shimmering after-images (palinopsias) and photophobia have been reported to be symptomatic in three cases for 2–7 years.
Conjunctival impression cytology by using a thermosensitive adhesive: polymerized N-isopropyl acrylamide
The cellular material was adequate for evaluation in 28 (93%) of 30 eyes in pNIPAM-coated parylene group and in 18 (60%) of 30 eyes in the nitrocellulose group (P= 0.0002). pNIPAM-coated parylene technique was superior to the nitrocellulose technique regarding the mean number of cells per microscopic field (P= 0.00003), integrity of the cells (P= 0.00001)
Neuroprotective Effects of Olanzapine in N-Methyl-d-Aspartate-Induced Retinal Injury
The aim of this study was to investigate the neuroprotective effect of olanzapine (OLA), an atypical antipsychotic drug, on N-methyl-d-aspartate (NMDA)-induced retinal injury.
A rare vascular disc abnormality associated with morning glory syndrome
Morning glory syndrome is a non-hereditary, usually unilateral malformation of the optic disc associated with various retinal abnormalities. We present a case of morning glory syndrome associated with a rare feature of different arteriolar circulation pattern of upper and lower halves of the optic disc.
Current Diagnostic and Management Methods in Orbital Tumors
In this review we evaluated correct diagnosis orbital tumors with curent diagnostic methods and current management approaches. Treatment of orbital tumors should be managed by cooperation of ocular oncologists with radiodiagnostics, pathology, radiation oncology, pediatric oncology and medical oncology specialists. With correct diagnostic and management techniques, orbital tumors may be treated by providing good quality of life for the patients.
Is a case of Sweet's syndrome associated with Behçet's Disease?
Oral aphthae, genital ulceration, uveitis, positive pathergy test and cutaneous vasculitis are diagnostic criteria of Behçet's disease. Similar symptoms may also appear in Sweet's syndrome. We report here a case of Sweet's syndrome associated with oral aphthae, erythema nodosum, episcleritis and positive pathergy test, with a history of upper respiratory tract infection and drug administration.
Cystoid macular edema early after uncomplicated cataract surgery: The efficacy of diclofenac in prophylaxis
Cystoid macular edema early after uncomplicated cataract surgery: The efficacy of diclofenac in prophylaxis
Ocular Hemodynamics In Non-Exudative Age Related Macular Degeneration
o explore changes in retrobulbar ocular blood flow dynamics in patients with nonexudative age-related macular degeneration (ARMD). Materials and Methods: 52 patients (M= 28, F= 24) with ARMD and 45 age-matched healthycontrols (M= 23, F= 22)
Blow-Out Fracture due to a Hazel Stick Beat
The aim of this case report is to demonstrate that blow-out fractures can occur not only by a classical trauma mechanism but also from the consequences of a stick beat. A 66-year-old male was admitted to our hospital complaining of a sudden swelling of his right eyelid after blowing his nose.
DIAGNOSIS AND TREATMENT IN MALIGNANT EYELID TUMORS
Malignant tumors may originate from any layer of the eyelid. Clinical and histopathological features, prognosis and treatment approaches differ depending on the tumor type. The aim of this reveiw is to discuss the key features in diagnosis and treatment of these tumors, to evaluate the differential diagnosis and treatment approaches for malignant eyelid tumors.
The Eye Cancer Network is supported by The Eye Cancer Foundation.
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