Pamela P Rath, MD
Everett and Hurite Ophthalmic Association
1835 Forbes Avenue, Pittsburgh, PA 15219
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- Everett and Hurite Ophthalmic Association
- Ophthalmic Oncologist
Education and Fellowships
- Moorfields Eye Hospital and St. Bartholomew's Hospital
- University of Minnesota
- Medical school
- SUNY Buffalo
Clinical Associate Professor Dept of Ophthalmology, UPMC
BOARD CERTIFIED BY AMERICAN BOARD OF OPHTHALMOLOGY (2003-Present)
LICENSURE: Pennsylvania and West Virginia
7/01 – 10/02
Fellowship, Moorfields Eye Hospital and St. Bartholomew’s Hospital, London, England (Ocular Oncology, Medical Retina, Inherited Diseases ERG)
7/98 – 6/01
Residency, Department of Ophthalmology, University of Minnesota, Minneapolis, MN
6/97 – 6/98
Internship, Hennepin County Medical Center, Minneapolis, MN
9/93 – 6/97
Medical School, State University of New York at Buffalo School of Medicine & Biomedical Sciences, Buffalo, NY
Indiana University of Pennsylvania Indiana, Pennsylvania
9/06 to Present Dept. of Ophthalmology, Clinical Associate Professor, University of Pittsburgh
12/02 to 8/06 Dept of Ophthalmology, Assistant Professor, University of Minnesota
04/08 to 4/11 Electrophysiology Consulting Dept of Ophthalmology, Univ of Minnesota
9/06 to 3/08 Electrophysiology Consulting, University of Pittsburgh ,
1/03 to 8/06 Director of Electrophysiology, Dept of Ophthalmology, University of Minnesota
9/04 to 8/06 Director of Ocular Oncology Program, University of Minnesota
9/16 to Present, Everett & Hurite Ophtalmic Association, Pittsburgh, PA
09/06 to 8/16, Retina Vitreous Consultants, Pittsburgh, PA
11/02 to 08/06, University of MN, Dept of Ophthalmology, Minneapolis, MN
CLINICAL RESEARCH TRIALS
AMPIO Study: Oral Danazole for treatment of diabetic macular edema. Randomized controlled trial evaluating placebo to two different doses of Danazole. Sponsor: Optina
Age-Related Eye Disease Study II (AREDS2): A Multi-center, Randomized Trial of Lutein, Zeaxanthin, and Omega-3 Long-Chain Polyunsaturated Omega-3 Fatty Acids (Docosahexaenoic Acid [DHA] and Eicosapentaenoic Acid [EPA]) in Age-Related Macular Degeneration. SPONSER: NIH
VIEW -1: A Randomized, Double Masked, Active Controlled Phase III Study of the Efficacy, Safety, and Tolerability of Repeated Doses of Intravitreal VEGF Trap in Subjects with Neovascular Age-Related Macular Degeneration Clinical Evaluation of Anti-angiogenesis in the Retina. Phase 3 trial. Sponsor: Eylea
POSURDEX AMD STUDY: A 2-year, phase III, multicenter, masked, randomized, sham controlled trial to assess the safety and efficacy of 700ug and 350ug Dexamethasone posterior segment drug delivery system (DEX PS DDS) applicator system in the treatment of patients with neovascular age related macular degeneration in conjunction with Lucentis. Sponsor: Allergan
CATT and CATT Extension Trial: Multicenter, randomized masked controlled study comparing the efficacy of Bevacizumab to Ranibizumab with both fixed and variable dosing for the treatment of exudative macular degeneration. Sponsor: NIH
DRCR network. Diabetic Retinopathy Clinical Research. Multiple clinical trials for the treatment of diabetic retinopathy.
Harbor trial: Comparison of standard and high dose Lucentis for treatment of exudatived macular deneration. Sponsor: Genentech
PIER STUDY: A Phase IIIb, multicenter, randomized double-masked, sham injection-controlled study of the efficacy and safety of ranibizumab in subjects with subfoveal choroidal neovascularization (CNV) with or without classic CNV secondary to age-related macular degeneration. Sponsor: Genentech
PROTOCOL FVF3426G: An open-label multicenter extension study to evaluate the safety and tolerability of Ranibizumab in subjects with subfoveal choroidal neovascularization (CNV) secondary to age-related macular degeneration (AMD) who have completed the treatment phase of genentech sponsored ranibizumab study. Sponsor: Genentech
SAILOR STUDY: A Phase IIIb, Single-Masked, Multicenter, Randomized Study to Evaluate the Safety and Tolerability of Ranibizumab in Naive and Previously Treated Subjects with Choroidal Neovascularization (CNV) Secondary to Age-Related Macular Degeneration (AMD). Sponsor: Genentech
VERITAS STUDY: A 24-month randomized, double- masked, sham controlled, multicenter, phase IIIB study comparing photodynamic therapy with verteporphin plus two different dose regimes of intravitreal triamcinolone acetonide (1mg AND 4 mg) versus visudyne plus intravitreal pegaptanib in patients with subfoveal choroidal neovascularization (CNV) secondary to age-related macular degeneration (AMD). Sponsor: Novartis
MBCU STUDY: The effect of ruboxistaurin on clinically significant macular edema in patients with diabetes mellitus, as assessed by optical coherence tomography. Sponsor:: Eli Lilly
POSURDEX DME STUDY: A 3-year, phase III, multicenter, masked, randomized, sham-controlled trial to assess the safety and efficacy of 700ug and 350ug Dexamethasone posterior segment drug delivery system (DEX PS DDS) applicator system in the treatment of patients with diabetic macular edema. Sponsor: Allergan
POSURDEX RVO STUDY: A six-month, phase III, multicenter, masked, randomized, sham-controlled trial (with six-month open label extension) to assess the safety and efficacy of 700ug and 350ug Dexamethasone posterior segment drug delivery system (DEX PS DDS) applicator system in the treatment of patients with macular edema following central retinal vein occlusion or branch retinal vein occlusion. Sponsor: Allergan
The Standard of Care vs. COrticosteroid for REtinal Vein Occlusion (SCORE) Study
DENALI: A 24-month randomized, double-masked, controlled, multicenter, phase IIIB study assessing safety and efficacy of verteporfin (Visudyne®) photodynamic therapy administered in conjunction with ranibizumab (Lucentis™) versus ranibizumab (Lucentis™) monotherapy in patients with subfoveal choroidal neovascularization secondary to age-related macular degeneration SPONSER:NOVARTIS
HONORS AND AWARDS
2000 Harry Friedman Research Award
2000 Harry Plotke Award (Clinical Skills and Patient Care)
2000 Richard T. Olson Best Teaching Award for Residents
1997 Research Honors
1997 Glasgow Award
1997 Dr. E. J. Weisenheimer Award (Scholarship and Patient Care in
1996 Alpha Omega Alpha Honor Medical Society
1996 Cowper Award (Ophthalmology Scholarship)
1995 James A. Gibson Anatomical Society Honorary Membership
1994-96 Dean's Letter of Commendation
2008 Retina Society
2006 Pennsylvania Ophthalmology Society
2006 The Pittsburgh Ophthalmology Society
2006 Allegheny County Medical Society
2006 Pennsylvania Medical Society
2004 International Society for Clinical Electrophysiology in Vision
2004 International Ocular Oncology Society
1999 American Medical Association
1998 Association for Research in Vision and Ophthalmology
1998 American Academy of Ophthalmology
TEACHING AND MENTORING ACTIVITIES
UPMC, Eye and Ear Institute Resident Teaching conferences, Annual Lectures: Retinal Toxicity (2006-2010), Electrophysiology (2006-2008, 2010, 2017), Inherited Retinal Diseases (2006-2016) retinitis pigmentosa (2009-present),
University of Minnesota Department of Ophthalmology Teaching conferences, 2002-2006, Annual Lectures: Electrophysiology, Inherited Retinal Diseases, Intraocular tumors, Retinoblastoma
School of Ophthalmic Medical Technology, 2003-2006
Annual Lecture: Basics of Electrophysiology
Faculty mentor for incoming ophthalmology residents, 2002-2006
PRESENTATION AND LECTURES
Retina Society Interesting Case Presentations, Philadelphia September 2014
International Society for Clinical Electrophysiology in Vision Interesting Case Presentations, Boston July 2014
Minnesota Academy of Ophthalmology. Inherited Retinal disease. January 2012
Retina Society Interesting Case Presentations, Washington D.C., September 2012
University of Minnesota Department of Ophthalmology. Ocular Oncology. January 2012
Case presentation: von Hippel Lindau with Bilateral Optic Nerve Hemangioblastomas. 1st Annual Wills Intraocular Tumor Symposium. April 2010.
Age Related Macular Degeneration (AMD). 29th Multidiscinplinary Aging Conference, University of Pittsburgh, Johnstown. October 2009.
Ocular Manifestations of Diabetes. Diabetes Update, University of Pittsburgh, Johnstown. March 2009
Update on Research for Retinal Degeneration, Foundation Fighting Blindness Pittsburgh Chapter, December 2007
Grand Rounds Presentation, Diffuse Choroidal Melanoma, Pittsburgh Ophthalmology Society Annual Meeting, Pittsburgh, PA March 2007
“Cherry Red Spot”, Upper Mississippi Valley Retina Cases Conference, Minneapolis, MN, May 2006.
“Update on Treatments for Age Related Macular Degeneration”, Park Nicollet Department of Ophthalmology Annual CME course, St Louis Park, MN, April 2006.
“Basics of B-scan Ultrasound” and “Update on Ocular Oncology”, Annual Ophthalmic Technician CME Course, Minneapolis, MN, May 2006.
“Basics of Diabetic Retinopathy”, University of Minnesota Department of Endocrinology Teaching Conference, Minneapolis, MN 2005.
“Pediatric Inherited Retinal Diseases” Minnesota Department of Ophthalmology Statewide Teachers Conference for Blind and Visually Impaired Students. Plymouth
“Basics of Electrophysiology” and “Update on Ocular Oncology”, Annual Ophthalmic Technician CME Course, Minneapolis, MN, May 2004
“Retinoblastoma”, University of Minnesota Department of Pediatrics Grand Rounds, Minneapolis, MN 2004, 2003.
“Update on Ocular Oncology”, Twin Cities Eye Meeting, Minneapolis, MN, April 2004.
“Maternally Inherited Diabetes and Deafness”, Twin Cities Eye Meeting, Minneapolis, MN, April 2003.
“Past, Present and Future of Retinoblastoma”, Retinoblastoma Society, London, England, September 2002.
“Acquired Retinal Disease”, Clinical Electrophysiology of Vision Course, London, England, March 2002.
Maternally Inherited Diabetes and Deafness, book chapter in Fundus Autofluorescence by N. Lois and J. V. Forrester, Lippincot Williams and Wilkins. 2009.
Clinical and histopathologic findings after photodynamic therapy of choroidal melanoma. Canal-Fontcuberta I, Salomão DR, Robertson D, Cantrill HL, Koozekanani D, Rath PP, Pulido JS. Retina 2012 May;32(5):942-8.
Histopathologically proven mucinous cystadenocarcinoma metastatic to the choroid. Henderson RH, Cohen VM, Rath PP, Luthert P, Hungerford JL. Retina Cases Brief Reports. 2010 Spring;4(2):181-3
Johnson MS, Christiansen SP, Rath PP, Watanabe TM, Merten G, Bothun ED, Anderson JS. Anterior ciliary circulation from the horizontal retctus muscles. Strabismus 2009 Jan-Mar;17(1):45-8.
Kutzbach B, Mendelsohn N, Rath P, Summers CG. Sectoral iris heterochromia and retinal pigment variation in 13q-syndrome: A case report. J AAPOS 11(5):513-515, 2007.
Subhadra C, Lee MS, Rath PP, Dudek AZ. Improvement in visual fields in a patient with melanoma-associated retinopathy treated with intravenous immunoglobulin. Journal of Neuro-Ophthalmology, 2008 Mar;28(1):23-6
Michaelides M, Jenkins SA, Bamiou D, Sweeney MG, Davis MB, Luxon L, Bird AC and Rath PP. Macular Dystrophy associated with the A3243G mitochondrial DNA mutation: distinct retinal and associated features, disease variability, characterization of asymptomatic family members. Archives of Ophthal, 2008 Mar;126(3):320-8.
PP Rath, S Jenkins, Michaelides M, A Smith, MG Sweeny, MB Davis, FW Fitzke, AC Bird. Characterization of the macular dystrophy in the A3243G mitochondrial DNA mutation with fundus autofluorescence. British J of Ophthal, 2008 May;92(5):623-9.
Bellmann C, Neveu MM, Scholl HPN, Rath PP, Bird AC, Holder GE. Localized retinal changes using electrophysiology and fundus autofluorescence imaging in patients with maternal inherited diabetes and deafness (MIDD). Invest Ophthalmol Vis. Sci. 2004 Jul; 45(7):2355-60.
Leroy BP, Hogg CR, Rath PP, McBain V, Kestelyn P, Bird AC, Holder GE. Clinical features & retinal function in patients with adult Refsum syndrome. Adv Exp Med Biol. 2003;544:57-8.
Olsen TW, Feng X, Kasper T, Rath PP, Steuer ER. Exudative Age Related Macular Degeneration: Fluorescein Angiographic Subtype Prevalence. Ophthalmology. 2004 Feb; 111(2):250-5.
Lincoff NS, Rath PP, Hirano M. A Treatment of Local Periocular Pain Due to Peripheral Nerve Damage. J of Neuroophthalmology 18(1):17-20, 1998.
Papo MC, Paczan PR, Fuhrman BP, Holm B, Fisher J, Steinhorn DM, Hernan LJ, Leach CL, Burak B. Perfluorocarbon associated gas exchange (PAGE) improves oxygenation, lung mechanics and survival in a model of adult respiratory distress syndrome. Crit Care Med 24(3):475-481, 1996.
Nesti FD, Fuhrman BP, Papo MC, Steinhorn DM, Hernan LJ, Leach CL, Holm B, Paczan P, Burak B. Perfluorocarbon-associated gas exchange (PAGE) in gastric aspiration. Crit Care Med 22(9):1445-1452, 1995.
Hernan LJ, Fuhrman BP, Paczan PR, Salman N, Papo MC, Steinhorn DM, Leach CL, Holm B. Cardiorespiratory effects of perfluorocarbon-associated gas exchange (PAGE) at reduced oxygen concentrations. Crit Care Med 23(3):553-559, 1995.
Hernan LJ, Fuhrman BP, Papo MC, Leach C, Thompson AE, Nesti F, Salman N, Steinhorn D, Novotny W, Paczan P, Burak B. Oxygenation during perfluorocarbon-associated gas exchange in normal and abnormal lungs. Biomater, Artific Cells, Immobil. 22:1377-1380, 1994.
Fuhrman BP, Paczan PR, DeFrancisis M. Perfluorocarbon associated gas exchange. Critical Care Medicine 19(5):712-723, 1991.
Canal-Fontcuberta I, Salomão DR, Robertson D, Cantrill HL, Koozekanani D, Rath PP, Pulido JS. Clinical and Histopathologic Findings After Photodynamic Therapy of Choroidal Melanoma. Retina. 2012 May;32(5):942-8
ABSTRACTS AND PRESENTATIONS
C. Bellmann, M. Neveu, H.P. Scholl, P.P. Rath, S. Jenkins, A.C. Bird, G.E. Holder. Retinal Function and fundus autofluorescence Imaging in patients with maternal inherited diabetes and deafness (MIDD). Presented at ARVO, Ft. Lauderdale, Florida, April 2003.
BP Leroy, CR Hogg, PRP Rath, FJGM Van Kuijk, FM Meire, Ph Kestelyn, AC Bird, GE Holder. Retinal Function in Patients with Adult Refsum Syndrome. Presented at ARVO, Ft. Lauderdale, Florida, April 2002
Bird AC, Smith A, Jenkins S, Rath P. Maternally Inherited Diabetes and Deafness. Presented at the Macula Society, Barcelona, June 2002
Rath PP, Jenkins S, Bird AC. Fundus Autofluorescence in Macular Dystrophy associated with Mitochondrial DNA Nucleotide A3243G Point Mutation. Presented at ARVO, Ft. Lauderdale, Florida, April 2002
Rath PP, Merten G, Watanabe T, McLoon L, Christiansen SP. Anterior Ciliary Circulation from the Lateral Rectus Muscles. Presented at AAPOS, San Diego, California, April 2000.
Rath PP, Hardten DH, Lindstrom RL, Chu YR, Witt B. Bilateral Sequential versus Unilateral Sequential Laser in situ Keratomileusis (LASIK) for the treatment of myopia. Presented at ARVO, Ft. Lauderdale, Florida, May 1999.
Rath PP, Steinhorn RH, Gugino SF, Morin FC, Russell JA. Pulmonary Vascular Guanylate Cyclase Activity in Newborn Lambs with Persistent Pulmonary Hypertension. State University of New York at Buffalo, School of Medicine and Biomedical Sciences Medical Student Research Forum, Buffalo, New York, 1995.
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