Virotherapy

Virotherapy
From TomTGC, April 12, 2005
Hello, The following excerpts are from Popular Science, May 2005. I wonder if virotherapy could be used for Metastatic Choroidal Melanoma? Tom Virotherapy In tests on mice afflicted with metastatic melanoma, a modified strain of HIV invaded cancer cells without affecting the rodents with AIDS. Around the same time, researchers at the Mayo Clinic in Rochester, Minnesota, announced similar results after engineering the measles virus to seek and destroy cancerous tumors while leaving healthy tissue unscathed. With preliminary studies showing many of these viruses to be safe for humans, several universities and biotech firms are now conducting clinical trials of virotherapy. P. 29 To outwit the body’s defenses, Russell devised a “targeted” measles virus, modifying its genome to express an antibody that shepherds it directly to the tumor. Likewise, the HIV strain in the UCLA melanoma study was targeted, and researchers have since tailored it to seek and destroy prostate and melanoma cancers. P. 30 Popular Science May 2005.
Re: Virotherapy
From jeremy, October 15, 2009
4 years later and ? Never heard this before.
Re: Re: Virotherapy
From paperdetective, February 1, 2012
The treatment of cancers with help of viruses (=oncolytic virus therapies) is actually the next big frontier, so a lot of money is being poured in it now and major drug companies recognize that too. See http://oncolyticvirus.wordpress.com/ Best melanoma related example of this is that in 2011 Amgen acquired BioVex, a biotech with its lead product OncoVEX oncolytic virus in phase III for advanced melanoma, for $ 1Bn.
Re: Re: Re: Virotherapy
From paperdetective, February 1, 2012
PS after the Amgen purchase the name Oncovex became TVEC. See http://www.biotechnologyevents.com/node/3673
Re: Re: Virotherapy
From paperdetective, February 1, 2012
Hier is de klinische studie van Oncovex in Engeland die in 2011 eindigde en waar men specifiek vroeg omm mensen met oof melanoom of andere melanomen die niot verwiderbaar zijn. Ziue http://cancerhelp.cancerresearchuk.org/trials/trial-oncovex-gmcsf-melanoma-cannot-be-removed
Re: Re: Virotherapy
From paperdetective, February 1, 2012
Apologies for the comment in Dutch (my native language). Here is the link to the British Oncovex (now TVEC) trial ended in 2011 where they specifically asked for ocular melanoman patients and other tumors which cannot be removed at http://cancerhelp.cancerresearchuk.org/trials/trial-oncovex-gmcsf-melanoma-cannot-be-removed.